Tommy Loan

Tommy Loan
University of Edinburgh
E-Mail Address
Started PhD
Apr 2020
PhD Title
Chemical probes for optical imaging of cancer
Project Summary

Synthesising probes comprised of near-infrared emitting dyes to specifically target T-cells, with potential applications in aiding immunotherapy and diagnostics.

Key Activities

Synthesised two  NIR-II cyanine dyes for deep tissue optical imaging.

Synthesised and optically characterised a library of novel photoswitching compounds. Used in-situ irradiation NMR to track structural changes of photoswtiches upon exposure to long-wave UV light.

Synthesised a switchable visible-range FRET probe for cancer-related protease, MALT-1.

Began testing of split-and-mix combinatorial library to determine the optimal peptide sequence of cancer-related protease, granzyme-B.

How Proteus is Helping Me Grow and Develop as a Researcher

Proteus has exposed me to different areas of research that I might not otherwise have sought out myself. I’ve learned about the different components of the system that are critical for my compound to be useful in optical imaging, from lasers to single-photon avalanche diode (SPAD) detectors to machine learning.